Welkom bij Health Data Space Utrecht, het portaal dat de regio Utrecht verbindt door onderzoekers en professionals samen te brengen om kennis en data te delen....
PREMIUM
Predicting Response of metastatic Melanoma to Immunotherapy Using Machine learning...
Description
Cohort of patients with advanced cutaneous melanoma treated with first-line immune checkpoint inhibition from 11 treatment centers in the Netherlands. Collected data: Clinical data (age, sex, treatment type, BRAF mutation status, WHO performance st...
General Design
- Type
- Cohort study, Databank
- Cohort type
- Clinical cohort
- Data collection type
- Retrospective, Prospective
- Design
- Cross-sectional
- Start/End data collection
- 2016 until 2023
- PID
- https://doi.org/10.71739/80pp-8882
Population
- Countries
- Netherlands (the)
- Number of participants
- 1941
- Population age groups
- Adult (18+ years)
- Main medical condition
- II Neoplasms
- C00-C97 Malignant neoplasms
- C00-C75 Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic and related tissue
- C43-C44 Melanoma and other malignant neoplasms of skin
- C43 Malignant melanoma of skin
- C43.0 Malignant melanoma of lip
- C43.1 Malignant melanoma of eyelid, including canthus
- C43.2 Malignant melanoma of ear and external auricular canal
- C43.3 Malignant melanoma of other and unspecified parts of face
- C43.4 Malignant melanoma of scalp and neck
- C43.5 Malignant melanoma of trunk
- C43.6 Malignant melanoma of upper limb, including shoulder
- C43.7 Malignant melanoma of lower limb, including hip
- C43.8 Overlapping malignant melanoma of skin
- C43.9 Malignant melanoma of skin, unspecified
- C44 Other malignant neoplasms of skin
- C44.0 Skin of lip
- C44.1 Skin of eyelid, including canthus
- C44.2 Skin of ear and external auricular canal
- C44.3 Skin of other and unspecified parts of face
- C44.4 Skin of scalp and neck
- C44.5 Skin of trunk
- C44.6 Skin of upper limb, including shoulder
- C44.7 Skin of lower limb, including hip
- C44.8 Overlapping lesion of skin
- C44.9 Malignant neoplasm of skin, unspecified
- Inclusion criteria
- Age group inclusion criterion
- Use of medication inclusion criterion
Organisations
Lead organisations
- University Medical Center Utrecht (UMC)Netherlands (the)https://www.umcutrecht.nl
Additional organisations
- The Netherlands Cancer Institute (NKI; NKI-AVL)Netherlands (the)https://www.nki.nl
- Radboud University Medical Center (RUNMC)Netherlands (the)https://www.radboudumc.nl
- Radboud University Medical Center (RUNMC)Netherlands (the)https://www.radboudumc.nl
- Leiden University Medical Center (LUMC)Netherlands (the)https://www.lumc.nl
- Zuyderland Medisch Centrum (OMC)Netherlands (the)https://www.zuyderland.nl/
- IsalaNetherlands (the)https://www.isala.nl
- Amsterdam University Medical CentersNetherlands (the)https://www.amsterdamumc.org
- University Medical Center Groningen (UMCG)Netherlands (the)https://www.umcg.nl
Available Data & Samples
Data categories
- Biological samples
- Imaging data
- Medical records
Sample categories
- Tissue (FFPE)
- Cardiovascular System - Tissue (FFPE)
- Digestive System - Tissue (FFPE)
- Endocrine system - Tissue (FFPE)
- Genitalia, Female - Tissue (FFPE)
- Genitalia, Male - Tissue (FFPE)
- Integumentary System - Tissue (FFPE)
- Lymphoid Tissue - Tissue (FFPE)
- Musculoskeletal System - Tissue (FFPE)
- Nervous System - Tissue (FFPE)
- Respiratory System - Tissue (FFPE)
- Sense Organs - Tissue (FFPE)
- Urogenital System - Tissue (FFPE)
Areas of information
- Socio-demographic and economic characteristics
- Age/birthdate
- Sex/gender
- Medication and supplements
- Medication and supplement intake
- Death
- Vital status
- Cause of death
- Other end of life or death-related information
- Physical measures and assessments
- Physical characteristics
- Laboratory measures
- Hematology
- Biochemistry
- Histology
Subpopulations
List of subpopulations for this resource...
| Name | Description | Number of participants | |
|---|---|---|---|
No results for current selection |
Collection events
List of collection events defined for this resource...
| Name | Description | Participants | Start end year | |
|---|---|---|---|---|
No results for current selection |
Networks
Part of networks...
Publications
A novel dataset for nuclei and tissue segmentation in melanoma with baseline nuclei segmentation and tissue segmentation benchmarks
A prediction model for response to immune checkpoint inhibition in advanced melanoma
Baseline tumor-infiltrating lymphocyte patterns and response to immune checkpoint inhibition in metastatic cutaneous melanoma
Body composition and checkpoint inhibitor treatment outcomes in advanced melanoma: a multicenter cohort study
CT radiomics compared to a clinical model for predicting checkpoint inhibitor treatment outcomes in patients with advanced melanoma
Deep learning on CT scans to predict checkpoint inhibitor treatment outcomes in advanced melanoma.
Imaging to predict checkpoint inhibitor outcomes in cancer. A systematic review
Time interval from primary melanoma to first distant recurrence in relation to patient outcomes in advanced melanoma
Tumor-infiltrating lymphocytes and immune-related adverse events in advanced melanoma
Access conditions
Data can only be used after approval of participating treatment centers....
- Data access conditions
- disease specific research
- Data use conditions
- collaboration required
- ethics approval required
- institution specific restriction
- Data access fee
- false
- Release type
- Closed dataset
- Prelinked
- false
Funding & Acknowledgements
- Funding
- This research was funded by The Netherlands Organization for Health Research and Development (ZonMW, project number 848101007), by an unrestricted grant of Stichting Hanarth Fonds, The Netherlands, and by Philips.